Superpotent halcinonide 0.1% cream once daily plus placebo twice daily versus halcinonide 0.1% cream three times daily for 3 weeksĬompared response between arms (much better, slightly better, or equal response) improvement in lesions categorised as excellent (75-100%), good (50-74%), fair (25-49%), and poor (20% of body surface involved)ġ21 children from various ethnic backgrounds in four sequential age cohorts (12-18 years, 6-12, 2-6, and 90% improvement) No data were given on relapse rates.ġ49 people with bilateral eczema pair wise comparisons were made setting not reported Clear evidence of a faster response with more frequent use or a better response in subgroups such as children was lacking. More importantly, none of the studies found clear evidence that applying topical corticosteroids more than once a day produced better overall clinical outcomes in eczema, such as the number of people with a good response. Although some statistically significant outcomes favouring twice daily applications were identified, these were not consistent for the type of outcome selected or between doctors and patients. 6 8 Quality of reporting of the studies was generally poor except in three cases. 8 One trial compared once versus twice daily moderately potent topical preparations eight studies evaluated once versus twice daily potent preparations one study compared once versus three times daily application of a super potent topical corticosteroid and one study compared once versus twice daily super potent topical corticosteroids. 6 7 Another short term study has been published more recently. The findings are summarised in a UK Health Technology Assessment report and guidance from the National Institute for Health and Clinical Excellence (NICE). Ten randomised controlled trials compared once daily versus more frequent application of topical corticosteroids within the same potency group (table (table).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |